The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

Edward A. Medina, Xiaoyu Shi, Marcia H. Grayson, Donna P. Ankerst, Carolina B. Livi, Maria V. Medina, Ian M. Thompson, Robin J. Leach

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Adiponectin has been reported to have a prohibitory effect on prostate cancer. The goal of this study was to evaluate the diagnostic value of adiponectin multimers for prostate cancer. Methods: Total adiponectin, high- and low-molecular-weight (HMW, LMW), ratios of these measures, and body mass index (BMI) were compared in a prospective prostate cancer-screened cohort. Multivariable logistic regression was used to assess the association between adiponectin measures, their interaction with BMI, and risk of prostate cancer and Gleason score upgrading from biopsy to prostatectomy. Results: A total of 228 prostate cancer cases and 239 controls were analyzed: 72 (31.6%) of the cancer cases were high grade (Gleason grade

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number2
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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