TY - JOUR
T1 - The development of the basal ganglia in Capuchin monkeys (Cebus apella)
AU - Phillips, Kimberley A.
AU - Sobieski, Courtney A.
AU - Gilbert, Valerie R.
AU - Chiappini-Williamson, Christine
AU - Sherwood, Chet C.
AU - Strick, Peter L.
N1 - Funding Information:
This work was supported by the National Science Foundation [ BCS-0515484 (CCS), BCS-0549117 (CCS), BCS-0827531 (CCS), DGE-0801634 (CCS)], National Institutes of Health [ NS42867 (CCS); NS24328 ; (PLS) MH056661 (PLS)], Wenner-Gren Foundation for Anthropological Research (CCS), James S. McDonnell Foundation [ 22002078 (CCS)], and Office of Research and Development, Medical Research Service, Department of Veterans Affairs (PLS). We thank Dr. Naftali Raz for sharing data on relative volumes of basal ganglia in humans.
PY - 2010/5/6
Y1 - 2010/5/6
N2 - The basal ganglia are subcortical structures involved in the planning, initiation and regulation of movement as well as a variety of non-motor, cognitive and affective functions. Capuchin monkeys share several important characteristics of development with humans, including a prolonged infancy and juvenile period, a long lifespan, and complex manipulative abilities. This makes capuchins important comparative models for understanding age-related neuroanatomical changes in these structures. Here we report developmental volumetric data on the three subdivisions of the basal ganglia, the caudate, putamen and globus pallidus in brown capuchin monkeys (Cebus apella). Based on a cross-sectional sample, we describe brain development in 28 brown capuchin monkeys (male n = 17, female n = 11; age range = 2 months-20 years) using high-resolution structural MRI. We found that the raw volumes of the putamen and caudate varied significantly with age, decreasing in volume from birth through early adulthood. Notably, developmental changes did not differ between sexes. Because these observed developmental patterns are similar to humans, our results suggest that capuchin monkeys may be useful animal models for investigating neurodevelopmental disorders of the basal ganglia.
AB - The basal ganglia are subcortical structures involved in the planning, initiation and regulation of movement as well as a variety of non-motor, cognitive and affective functions. Capuchin monkeys share several important characteristics of development with humans, including a prolonged infancy and juvenile period, a long lifespan, and complex manipulative abilities. This makes capuchins important comparative models for understanding age-related neuroanatomical changes in these structures. Here we report developmental volumetric data on the three subdivisions of the basal ganglia, the caudate, putamen and globus pallidus in brown capuchin monkeys (Cebus apella). Based on a cross-sectional sample, we describe brain development in 28 brown capuchin monkeys (male n = 17, female n = 11; age range = 2 months-20 years) using high-resolution structural MRI. We found that the raw volumes of the putamen and caudate varied significantly with age, decreasing in volume from birth through early adulthood. Notably, developmental changes did not differ between sexes. Because these observed developmental patterns are similar to humans, our results suggest that capuchin monkeys may be useful animal models for investigating neurodevelopmental disorders of the basal ganglia.
KW - Basal ganglia
KW - Brain development
KW - Cebus
UR - http://www.scopus.com/inward/record.url?scp=77950859903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950859903&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2010.03.017
DO - 10.1016/j.brainres.2010.03.017
M3 - Article
C2 - 20227397
AN - SCOPUS:77950859903
SN - 0006-8993
VL - 1329
SP - 82
EP - 88
JO - Brain Research
JF - Brain Research
ER -