The development of erectile dysfunction in men treated for prostate cancer

Timothy Siegel, Judd W. Moul, Marianne Spevak, W. Gregory Alvord, Raymond A. Costabile, Ian M. Thompson

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Purpose: Erectile dysfunction is a common side effect in men treated for prostate cancer. Previously published studies document the incidence of erectile dysfunction in men treated for prostate cancer to be between 20% and 88%. To our knowledge a prospective evaluation focused on the development of erectile dysfunction in men treated for prostate cancer has not elucidated components of its chronology or risk factors. Materials and Methods: A centralized prospective database of 2,956 patients diagnosed with prostate cancer at a single institution was studied in regard to pretreatment and posttreatment erectile dysfunction. Of these 2,956 patients 802 had sufficient information regarding erectile function and comprise our study population. Factors analyzed in regard to treatment and erectile dysfunction include treatment modality, that is radical prostatectomy, external beam radiation therapy and watchful waiting, and ethnicity, patient age, clinical stage and tumor histological grade. Results: No significant difference was noted in the posttreatment erectile function between patients treated with radical prostatectomy or external beam radiation (10% versus 15%). Patients selecting watchful waiting had the lowest risk of erectile dysfunction. Clinical stage and race were significant predictors for the development of erectile dysfunction in the watchful waiting and external beam radiation treatment groups. Conclusions: Erectile dysfunction develops in greater than 80% of patients treated for prostate cancer. External beam radiation has the same risk for erectile dysfunction as radical prostatectomy.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalJournal of Urology
Volume165
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Impotence
  • Prostatic neoplasms
  • Therapeutics

ASJC Scopus subject areas

  • Urology

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    Siegel, T., Moul, J. W., Spevak, M., Alvord, W. G., Costabile, R. A., & Thompson, I. M. (2001). The development of erectile dysfunction in men treated for prostate cancer. Journal of Urology, 165(2), 430-435. https://doi.org/10.1097/00005392-200102000-00019