The detection of weak allogeneic stimulation by DR-positive tumor cell lines

M. S. Pollack

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The experiments described in this report indicate that a method has not been established whereby the functional properties of the DR antigens that are expressed on many cultured melanoma cell lines and a few other cultured human tumor cell types can be studied. As in the case of lymphoblastoid cell lines, cultured melanoma cells appear to be highly resistant to the effects of gamma radiation or mitomycin-C on their spontaneous proliferative activity. Gluteraldehyde treatment, which can be shown to render lymphoblastoid cell lines free of spontaneous proliferative activity yet fully capable of stimulating allogeneic lymphocytes, can also be used for similar studies with cultured melanoma cells. In the preliminary studies conducted using this new procedure, it is evident that a weak but significant level of allogeneic stimulation in primary cell culture can indeed be detected.

Original languageEnglish (US)
Pages (from-to)1947-1951
Number of pages5
JournalTransplantation Proceedings
Volume13
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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