The default mode network and related right hemisphere structures may be the key substrates of dementia

Donald R. Royall, Raymond F. Palmer, Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together g' and d comprise Spearman's "g". Although d represents only a minor fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g'. In this analysis, we replicate δ in a new dataspace, the University of Kansas Brain Aging Project, and associate it specifically with regional grey matter atrophy by voxel-based morphometry of magnetic resonance imaging data. The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere.

Original languageEnglish (US)
Pages (from-to)467-478
Number of pages12
JournalJournal of Alzheimer's Disease
Volume32
Issue number2
DOIs
StatePublished - 2012

Keywords

  • Aging
  • cognition
  • dementia
  • functional status
  • g

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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