The default mode network and related right hemisphere structures may be the key substrates of dementia

Donald R Royall, Ray Palmer, Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together g' and d comprise Spearman's "g". Although d represents only a minor fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g'. In this analysis, we replicate δ in a new dataspace, the University of Kansas Brain Aging Project, and associate it specifically with regional grey matter atrophy by voxel-based morphometry of magnetic resonance imaging data. The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere.

Original languageEnglish (US)
Pages (from-to)467-478
Number of pages12
JournalJournal of Alzheimer's Disease
Volume32
Issue number2
DOIs
StatePublished - 2012

Fingerprint

Task Performance and Analysis
Dementia
Structural Models
Atrophy
Magnetic Resonance Imaging
Brain
Gray Matter

Keywords

  • Aging
  • cognition
  • dementia
  • functional status
  • g

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

The default mode network and related right hemisphere structures may be the key substrates of dementia. / Royall, Donald R; Palmer, Ray; Vidoni, Eric D.; Honea, Robyn A.; Burns, Jeffrey M.

In: Journal of Alzheimer's Disease, Vol. 32, No. 2, 2012, p. 467-478.

Research output: Contribution to journalArticle

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