The decidual cell response in aging C57BL/6J mice is potentiated by long-term ovariectomy and chronic food restriction

G. J. Goodrick, James F Nelson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of long-term ovariectomy (LOVX) and chronic food restriction on the decidual cell response were examined in aging mice. At 2 mos of age, mice were either ovariectomized, started on a regimen of food restriction (70% of ad lib intake), or left untreated. At 10 mos, the decidual cell response (DCR) was induced in all groups and measured by uterine weight gain, alkaline phosphatase activity, and DNA content. The DCR was also examined in young (4.5 mos) mice. LOVX and, to a lesser extent, food restriction (FR) potentiated the DCR, as indicated by 20-75% greater alkaline phosphatase activity and uterine weight relative to age-matched controls. In contrast to previous reports, however, there was no age-related reduction of the DCR. These results show that both LVOX and FR can enhance uterine function in middle-aged mice and indicate that, under some experimental conditions, there is no age-related impairment in the DCR.

Original languageEnglish (US)
JournalJournals of Gerontology
Volume44
Issue number3
StatePublished - 1989
Externally publishedYes

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Ovariectomy
Inbred C57BL Mouse
Food
Alkaline Phosphatase
Weight Gain
Weights and Measures
DNA

ASJC Scopus subject areas

  • Aging

Cite this

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title = "The decidual cell response in aging C57BL/6J mice is potentiated by long-term ovariectomy and chronic food restriction",
abstract = "The effects of long-term ovariectomy (LOVX) and chronic food restriction on the decidual cell response were examined in aging mice. At 2 mos of age, mice were either ovariectomized, started on a regimen of food restriction (70{\%} of ad lib intake), or left untreated. At 10 mos, the decidual cell response (DCR) was induced in all groups and measured by uterine weight gain, alkaline phosphatase activity, and DNA content. The DCR was also examined in young (4.5 mos) mice. LOVX and, to a lesser extent, food restriction (FR) potentiated the DCR, as indicated by 20-75{\%} greater alkaline phosphatase activity and uterine weight relative to age-matched controls. In contrast to previous reports, however, there was no age-related reduction of the DCR. These results show that both LVOX and FR can enhance uterine function in middle-aged mice and indicate that, under some experimental conditions, there is no age-related impairment in the DCR.",
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T1 - The decidual cell response in aging C57BL/6J mice is potentiated by long-term ovariectomy and chronic food restriction

AU - Goodrick, G. J.

AU - Nelson, James F

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N2 - The effects of long-term ovariectomy (LOVX) and chronic food restriction on the decidual cell response were examined in aging mice. At 2 mos of age, mice were either ovariectomized, started on a regimen of food restriction (70% of ad lib intake), or left untreated. At 10 mos, the decidual cell response (DCR) was induced in all groups and measured by uterine weight gain, alkaline phosphatase activity, and DNA content. The DCR was also examined in young (4.5 mos) mice. LOVX and, to a lesser extent, food restriction (FR) potentiated the DCR, as indicated by 20-75% greater alkaline phosphatase activity and uterine weight relative to age-matched controls. In contrast to previous reports, however, there was no age-related reduction of the DCR. These results show that both LVOX and FR can enhance uterine function in middle-aged mice and indicate that, under some experimental conditions, there is no age-related impairment in the DCR.

AB - The effects of long-term ovariectomy (LOVX) and chronic food restriction on the decidual cell response were examined in aging mice. At 2 mos of age, mice were either ovariectomized, started on a regimen of food restriction (70% of ad lib intake), or left untreated. At 10 mos, the decidual cell response (DCR) was induced in all groups and measured by uterine weight gain, alkaline phosphatase activity, and DNA content. The DCR was also examined in young (4.5 mos) mice. LOVX and, to a lesser extent, food restriction (FR) potentiated the DCR, as indicated by 20-75% greater alkaline phosphatase activity and uterine weight relative to age-matched controls. In contrast to previous reports, however, there was no age-related reduction of the DCR. These results show that both LVOX and FR can enhance uterine function in middle-aged mice and indicate that, under some experimental conditions, there is no age-related impairment in the DCR.

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