The D2 dopamine receptor gene as a predictor fo compulsive disease: Bayes' theorem

K. Blum, R. C. Wood, E. R. Braverman, T. J.H. Chen, P. J. Sheridan

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the meso-limbic circuitry of the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance (alcohol, drug, tobacco and food) seeking behavior. Decades of research indicate that genetics play an important role in vulnerability to severe substance seeking behavior. We propose that variants of the D2 dopamine receptor gene are important common genetic determinants in predicting compulsive disease.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalFunctional Neurology
Volume10
Issue number1
StatePublished - 1995

Keywords

  • Alcoholism
  • Attention-deficit-hyperactivity disorder
  • Compulsive disease
  • D2 receptors
  • Dopamine
  • Substance use disorders

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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