The current status of haemoglobin-based blood substitutes

Stephen M. Cohn

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Haemoglobin-based red cell substitutes have recently passed a myriad of safety studies and are now undergoing efficacy evaluation. There are numerous potential benefits with use of these solutions: they are readily available and have a long shelf-life; do not require typing and cross-matching; are free of viral or bacterial contamination; lack the immunosuppressive effects of blood; and have a much lower viscosity than blood. One-third of the 10 million units of blood transfused in the United States each year is utilized in the emergency setting. Therefore, a safe, effective substitute for blood should have significant impact upon the way we resuscitate bleeding patients. In this article, the current status of the various haemoglobin-based red cell substitutes is reviewed.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalAnnals of Medicine
Issue number5
StatePublished - Jan 1 1997


  • Haemoglobin-based red cell substitutes
  • Resuscitation

ASJC Scopus subject areas

  • Medicine(all)


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