The critical role of inflammation in the pathogenesis and progression of myeloid malignancies

Brianna M. Craver, Kenza El Alaoui, Robyn M. Scherber, Angela G. Fleischman

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Hematopoietic stem cells (HSCs) maintain an organism’s immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are characteristically high in patients with myeloid malignancies and are linked to disease initiation, symptom burden, disease progression, and worsened prognostic survival. This review will cover our current understanding of the role of inflammation in the initiation, progression, and complications of myeloid hematologic malignancies, drawing from clinical studies as well as murine models. We will also highlight inflammation as a therapeutic target in hematologic malignancies.

Original languageEnglish (US)
Article number104
JournalCancers
Volume10
Issue number4
DOIs
StatePublished - Apr 2018
Externally publishedYes

Keywords

  • Clonal hematopoiesis
  • Hematopoietic stem cells
  • Inflammation
  • Myeloid malignancy
  • Symptom burden

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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