The contribution of experimental models to our understanding of the pathogenesis and treatment of bronchopulmonary dysplasia

R. A. DeLemos, J. J. Coalson

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

In the 12 years since a National Institute of Health workshop on bronchopulmonary dysplasia (BPD) recommended that emphasis be placed on the development of animal models to further understand disease, there has been considerable progress in this area. Data from nonhuman primate homologs of BPD and animal models of specific lung injuries have served to expand and refine our understanding of pathogenesis. Recent studies examining the changes in gene expression associated with premature delivery and survival suggest that there are isolated aberrations that may account for some of the increased susceptibility of the immature lung to injury.

Original languageEnglish (US)
Pages (from-to)521-539
Number of pages19
JournalClinics in Perinatology
Volume19
Issue number3
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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