The complexity of Tox T-dependent transcription in Vibrio cholerae

Gregor G. Weber, Karl E. Klose

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalIndian Journal of Medical Research
Volume133
Issue number2
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • AraC family
  • Cholera
  • Pathogenicity island
  • Transcription activation
  • Virulence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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