The Complete Sequence of Leishmania RNA Virus LRV2-1, a Virus of an Old World Parasite Strain

Scott M. Scheffter, Young T. Ro, In K. Chung, J. L. Patterson

    Research output: Contribution to journalArticlepeer-review

    64 Scopus citations

    Abstract

    A complete cDNA sequence is reported for LRV2-1, the first Leishmania RNA virus known to infect an Old World parasite, Leishmania major. Sequence analyses show that LRV2-1 differs significantly from members of the LRV1 genus which infect New World parasites. The data support a view that transmission of LRV is strictly vertical and suggest that LRV predate the divergence of Old and New World parasites. As a consequence of this divergence, conserved features can be identified for the first time in Leishmania virus proteins. A finding that the virus capsid and polymerase genes do not overlap is unique among the known Totiviridae and infers that a gag-pol fusion protein cannot be produced simply via tRNA slippage in LRV2-1.

    Original languageEnglish (US)
    Article number71456
    Pages (from-to)84-90
    Number of pages7
    JournalVirology
    Volume212
    Issue number1
    DOIs
    StatePublished - Sep 10 1995

    ASJC Scopus subject areas

    • Virology

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