TY - JOUR
T1 - The common marmoset monkey
T2 - Avenues for exploring the prenatal, placental, and postnatal mechanisms in developmental programming of pediatric obesity
AU - Riesche, Laren
AU - Tardif, Suzette D.
AU - Ross, Corinna N.
AU - Demartelly, Victoria A.
AU - Ziegler, Toni
AU - Rutherford, Julienne N.
N1 - Funding Information:
Funding was provided in part by the Robert Wood Johnson Future of Nursing Scholars program (Riesche) and by the National Institutes of Health (R01-DK-077639 to S.D.Tardif and R01-HD-076018 to J. N. Rutherford).
PY - 2018/5
Y1 - 2018/5
N2 - Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey (Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.
AB - Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey (Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.
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U2 - 10.1152/ajpregu.00164.2017
DO - 10.1152/ajpregu.00164.2017
M3 - Review article
C2 - 29412686
AN - SCOPUS:85046890059
VL - 314
SP - R684-R692
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 5
ER -