The clinical and molecular epidemiology of bacteremias at a University Hospital caused by pneumococci not susceptible to penicillin

Francisco Moreno, Cindy Crisp, James H. Jorgensen, Jan E Patterson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

To determine the epidemiology of bacteremias due to pneumococci not susceptible to penicillin (PNSP) at a university hospital, active microbiologic surveillance of bacteremias due to PNSP was done for 28 months. Controls were bacteremias caused by penicillin-susceptible pneumococci. Antimicrobial susceptibilities for alternative antibiotics were determined. Pulsed-field gel electrophoresis (PFGE) and serotyping were used as markers of strain identity. Of 113 pneumococcal isolates, 14 (13%) were intermediate or resistant to penicillin (MIC ≥ 0.1 μg/mL). Twelve PNSP were resistant to other drugs: chloramphenicol (5), tetracycline (6), trimethoprim- sulfamethoxazole (5), cefotaxime (1), and erythromycin (1). Independently significant risk factors associated with PNSP bacteremia were sepsis and prior treatment with β-lactam antibiotics. PFGE revealed 10 distinguishable patterns among 12 isolates available for typing. In general, PFGE typing correlated with serotyping. It also distinguished some isolates of the same serotype. PFGE typing and serotyping suggest that the frequency of PNSP in the San Antonio, Texas, area is not due to dissemination of a single clonal strain.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalJournal of Infectious Diseases
Volume172
Issue number2
StatePublished - Aug 1995

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Molecular Epidemiology
Bacteremia
Streptococcus pneumoniae
Penicillins
Pulsed Field Gel Electrophoresis
Serotyping
Anti-Bacterial Agents
Lactams
Cefotaxime
Sulfamethoxazole Drug Combination Trimethoprim
Chloramphenicol
Erythromycin
Tetracycline
Sepsis
Epidemiology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The clinical and molecular epidemiology of bacteremias at a University Hospital caused by pneumococci not susceptible to penicillin. / Moreno, Francisco; Crisp, Cindy; Jorgensen, James H.; Patterson, Jan E.

In: Journal of Infectious Diseases, Vol. 172, No. 2, 08.1995, p. 427-432.

Research output: Contribution to journalArticle

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