The cholinergic system in rat striatum during morphine tolerance and dependence

A. Schurr, B. M. Rigor, R. Strong, Z. Gottesfeld

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Male Sprague-Dawley rats were used in the present study to assess the effects of chronic treatment of morphine on the striatal cholinergic system. The results demonstrate that neither short nor long-term morphine treatment had an effect on choline acetyltransferase (ChAT) activity or 3H- quinuclidinylbenzilate (3HQNB) binding in discrete striatal regions of the rat brain.

Original languageEnglish (US)
Pages (from-to)2521-2525
Number of pages5
JournalLife Sciences
Volume33
Issue number25
DOIs
StatePublished - Dec 19 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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