The changing landscape of gene editing tool delivery in neurological disorders

Yu Ju Chen, Abhik Paul, Michael Gregory Collins, Hye Young Lee

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.

Original languageEnglish (US)
Article number100509
JournalCurrent Opinion in Biomedical Engineering
StatePublished - Dec 2023


  • Brain disorders
  • CRISPR/Cas9
  • Gene editing
  • Nnonviral vector

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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