The changing landscape of gene editing tool delivery in neurological disorders

Yu Ju Chen; Abhik Paul; Michael Gregory Collins; Hye Young Lee

doi:10.1016/j.cobme.2023.100509

The changing landscape of gene editing tool delivery in neurological disorders

Yu Ju Chen, Abhik Paul, Michael Gregory Collins, Hye Young Lee

Department of Cellular & Integrative Physiology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.

Original language	English (US)
Article number	100509
Journal	Current Opinion in Biomedical Engineering
Volume	28
DOIs	https://doi.org/10.1016/j.cobme.2023.100509
State	Published - Dec 2023

Keywords

Brain disorders
CRISPR/Cas9
Gene editing
Nnonviral vector

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1016/j.cobme.2023.100509

Cite this

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title = "The changing landscape of gene editing tool delivery in neurological disorders",

abstract = "The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.",

keywords = "Brain disorders, CRISPR/Cas9, Gene editing, Nnonviral vector",

author = "Chen, {Yu Ju} and Abhik Paul and Collins, {Michael Gregory} and Lee, {Hye Young}",

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year = "2023",

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language = "English (US)",

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AU - Paul, Abhik

AU - Collins, Michael Gregory

AU - Lee, Hye Young

PY - 2023/12

Y1 - 2023/12

N2 - The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.

AB - The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.

KW - Brain disorders

KW - CRISPR/Cas9

KW - Gene editing

KW - Nnonviral vector

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DO - 10.1016/j.cobme.2023.100509

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VL - 28

JO - Current Opinion in Biomedical Engineering

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The changing landscape of gene editing tool delivery in neurological disorders

Abstract

Keywords

ASJC Scopus subject areas

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