The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy

Payal K. Patel; Joshua E. Erlandsen; William R. Kirkpatrick; Deborah K. Berg; Steven D. Westbrook; Christopher Louden; John E. Cornell; George R. Thompson; Ana C. Vallor; Brian L. Wickes; Nathan P. Wiederhold; Spencer W. Redding; Thomas F. Patterson

doi:10.1155/2012/262471

The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy

Payal K. Patel, Joshua E. Erlandsen, William R. Kirkpatrick, Deborah K. Berg, Steven D. Westbrook, Christopher Louden, John E. Cornell, George R. Thompson, Ana C. Vallor, Brian L. Wickes, Nathan P. Wiederhold, Spencer W. Redding, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The impact of antiretroviral therapy (ART) on opportunistic conditions in HIV patients continues to evolve. We specifically studied the changing epidemiology of oropharyngeal candidiasis (OPC) in 215 HIV/AIDS patients. Status of yeast colonization was assessed from oral rinse samples, and preliminary yeast identification was made using CHROMagar Candida and confirmed with standard microbiological techniques and/or molecular sequencing. Susceptibility to fluconazole was determined by CHROMagar Candida agar dilution screening and CLSI broth microdilution. 176 (82%) patients were colonized and 59 (27%) patients had symptomatic OPC. Candida albicans was the most prevalent species, though C. glabrata and C. dubliniensis were detected in 29% of isolates. Decreased fluconazole susceptibility occurred in 10% of isolates. Previous ART reduced the risk of OPC, while smoking increased the risk of colonization. Oral yeast colonization and symptomatic infection remain common even with advances in HIV therapy. C. albicans is the most common species, but other yeasts are prevalent and may have decreased susceptibility to fluconazole.

Original language	English (US)
Article number	262471
Journal	AIDS Research and Treatment
Volume	2012
DOIs	https://doi.org/10.1155/2012/262471
State	Published - 2012

ASJC Scopus subject areas

Immunology and Allergy
Dermatology
Public Health, Environmental and Occupational Health
Infectious Diseases

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Patel, P. K., Erlandsen, J. E., Kirkpatrick, W. R., Berg, D. K., Westbrook, S. D., Louden, C., Cornell, J. E., Thompson, G. R., Vallor, A. C., Wickes, B. L., Wiederhold, N. P., Redding, S. W., & Patterson, T. F. (2012). The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy. AIDS Research and Treatment, 2012, [262471]. https://doi.org/10.1155/2012/262471

The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy. / Patel, Payal K.; Erlandsen, Joshua E.; Kirkpatrick, William R.; Berg, Deborah K.; Westbrook, Steven D.; Louden, Christopher; Cornell, John E.; Thompson, George R.; Vallor, Ana C.; Wickes, Brian L.; Wiederhold, Nathan P.; Redding, Spencer W.; Patterson, Thomas F.

In: AIDS Research and Treatment, Vol. 2012, 262471, 2012.

Research output: Contribution to journal › Article › peer-review

Patel, PK, Erlandsen, JE, Kirkpatrick, WR, Berg, DK, Westbrook, SD, Louden, C, Cornell, JE, Thompson, GR, Vallor, AC, Wickes, BL, Wiederhold, NP, Redding, SW & Patterson, TF 2012, 'The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy', AIDS Research and Treatment, vol. 2012, 262471. https://doi.org/10.1155/2012/262471

Patel, Payal K. ; Erlandsen, Joshua E. ; Kirkpatrick, William R. ; Berg, Deborah K. ; Westbrook, Steven D. ; Louden, Christopher ; Cornell, John E. ; Thompson, George R. ; Vallor, Ana C. ; Wickes, Brian L. ; Wiederhold, Nathan P. ; Redding, Spencer W. ; Patterson, Thomas F. / The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy. In: AIDS Research and Treatment. 2012 ; Vol. 2012.

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abstract = "The impact of antiretroviral therapy (ART) on opportunistic conditions in HIV patients continues to evolve. We specifically studied the changing epidemiology of oropharyngeal candidiasis (OPC) in 215 HIV/AIDS patients. Status of yeast colonization was assessed from oral rinse samples, and preliminary yeast identification was made using CHROMagar Candida and confirmed with standard microbiological techniques and/or molecular sequencing. Susceptibility to fluconazole was determined by CHROMagar Candida agar dilution screening and CLSI broth microdilution. 176 (82%) patients were colonized and 59 (27%) patients had symptomatic OPC. Candida albicans was the most prevalent species, though C. glabrata and C. dubliniensis were detected in 29% of isolates. Decreased fluconazole susceptibility occurred in 10% of isolates. Previous ART reduced the risk of OPC, while smoking increased the risk of colonization. Oral yeast colonization and symptomatic infection remain common even with advances in HIV therapy. C. albicans is the most common species, but other yeasts are prevalent and may have decreased susceptibility to fluconazole.",

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