The challenge of HIV-1 subtype diversity

Barbara S. Taylor, Magdalena E. Sobieszczyk, Francine E. McCutchan, Scott M. Hammer

Research output: Contribution to journalReview articlepeer-review

373 Scopus citations


HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development.

Original languageEnglish (US)
Pages (from-to)1590
Number of pages1
JournalNew England Journal of Medicine
Issue number15
StatePublished - Apr 10 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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