The challenge of HIV-1 subtype diversity

Barbara Taylor, Magdalena E. Sobieszczyk, Francine E. McCutchan, Scott M. Hammer

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development.

Original languageEnglish (US)
JournalNew England Journal of Medicine
Volume358
Issue number15
DOIs
StatePublished - Apr 10 2008
Externally publishedYes

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HIV-1
Disease Progression
Vaccines
Viruses
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The challenge of HIV-1 subtype diversity. / Taylor, Barbara; Sobieszczyk, Magdalena E.; McCutchan, Francine E.; Hammer, Scott M.

In: New England Journal of Medicine, Vol. 358, No. 15, 10.04.2008.

Research output: Contribution to journalArticle

Taylor, Barbara ; Sobieszczyk, Magdalena E. ; McCutchan, Francine E. ; Hammer, Scott M. / The challenge of HIV-1 subtype diversity. In: New England Journal of Medicine. 2008 ; Vol. 358, No. 15.
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