The blood-spinal cord barrier: Morphology and clinical implications

Viktor Bartanusz, Daniela Jezova, Betty Alajajian, Murat Digicaylioglu

Research output: Contribution to journalReview articlepeer-review

191 Scopus citations

Abstract

The blood-spinal cord barrier (BSCB) is the functional equivalent of the blood-brain barrier (BBB) in the sense of providing a specialized microenvironment for the cellular constituents of the spinal cord. Even if intuitively the BSCB could be considered as the morphological extension of the BBB into the spinal cord, evidence suggests that this is not so. The BSCB shares the same principal building blocks with the BBB; nevertheless, it seems that morphological and functional differences may exist between them. Dysfunction of the BSCB plays a fundamental role in the etiology or progression of several pathological conditions of the spinal cord, such as spinal cord injury, amyotrophic lateral sclerosis, and radiation-induced myelopathy. This review summarizes current knowledge of the morphology of the BSCB, the methodology of studying the BSCB, and the potential role of BSCB dysfunction in selected disorders of the spinal cord, and finally summarizes therapeutic approaches to the BSCB.

Original languageEnglish (US)
Pages (from-to)194-206
Number of pages13
JournalAnnals of neurology
Volume70
Issue number2
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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