The biphasic morphology of voluntary and spontaneous single muscle fiber action potentials

Daniel Dumitru, John C. King, William van der Rijt, Dick F. Stegeman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The extracellular morphology of single muscle fiber action potentials (SMFAPs) is anticipated by volume conductor theory to be triphasic. Single muscle fiber action potentials recorded during single muscle fiber studies (500 Hz to 20 kHz) usually appear triphasic; however, when recorded with an open bandwidth (1 Hz to 20 kHz) they are found to be biphasic. Fibrillation potentials recorded with a single fiber electrode and open bandwidth have identical biphasic morphologies as volitional SMFAPs. Computer simulations suggest that the intracellular action potential models currently used to derive simulated extracellularly recorded SMFAPs must have the repolarization phase considerably prolonged to yield the clinically recorded potentials. This implies that either the models presently used require significant modification, or there is some distortion of the transmembrane source current induced in needle recording studies such that biphasic and not triphasic potentials are detected. © 1994 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)1301-1307
Number of pages7
JournalMuscle & Nerve
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 1994

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Keywords

  • fibrillation potentials
  • model simulations
  • single muscle fiber action potentials
  • volume conduction

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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