TY - JOUR
T1 - The BEIR VII estimates of low-dose radiation health risks are based on faulty assumptions and data analyses
T2 - A call for reassessment
AU - Siegel, Jeffry A.
AU - Greenspan, Bennett S.
AU - Maurer, Alan H.
AU - Taylor, Andrew T.
AU - Phillips, William T.
AU - Van Nostrand, Douglas
AU - Sacks, Bill
AU - Silberstein, Edward B.
N1 - Publisher Copyright:
© 2018 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - The 2006 National Academy of Sciences Biologic Effects of Ionizing Radiation (BEIR) VII report is a well-recognized and frequently cited source on the legitimacy of the linear no-threshold (LNT) model-a model entailing a linear and causal relationship between ionizing radiation and human cancer risk. Linearity means that all radiation causes cancer and explicitly excludes a threshold below which radiogenic cancer risk disappears. However, the BEIR VII committee has erred in the interpretation of its selected literature; specifically, the in vitro data quoted fail to support LNT. Moreover, in vitro data cannot be considered as definitive proof of cancer development in intact organisms. This review is presented to stimulate a critical reevaluation by a BEIR VIII committee to reassess the validity, and use, of LNT and its derived policies.
AB - The 2006 National Academy of Sciences Biologic Effects of Ionizing Radiation (BEIR) VII report is a well-recognized and frequently cited source on the legitimacy of the linear no-threshold (LNT) model-a model entailing a linear and causal relationship between ionizing radiation and human cancer risk. Linearity means that all radiation causes cancer and explicitly excludes a threshold below which radiogenic cancer risk disappears. However, the BEIR VII committee has erred in the interpretation of its selected literature; specifically, the in vitro data quoted fail to support LNT. Moreover, in vitro data cannot be considered as definitive proof of cancer development in intact organisms. This review is presented to stimulate a critical reevaluation by a BEIR VIII committee to reassess the validity, and use, of LNT and its derived policies.
KW - BEIR VII
KW - Linear no-threshold
KW - Radiological imaging
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U2 - 10.2967/jnumed.117.206219
DO - 10.2967/jnumed.117.206219
M3 - Article
C2 - 29475999
AN - SCOPUS:85049404352
VL - 59
SP - 1017
EP - 1019
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 7
ER -