The baboon model (Papio hamadryas) of fetal loss: Maternal weight, age, reproductive history and pregnancy outcome

Natalia E. Schlabritz-Loutsevitch, Charleen M. Moore, Juan Carlos Lopez-Alvarenga, Betty G. Dunn, Donald Dudley, Gene B. Hubbard

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Background: Several risk factors are associated with the incidence of human stillbirths. The prevention of stillbirths in women is a pressing clinical problem. Methods: We reviewed 402 pathology records of fetal loss occurring in a large baboon (Papio spp.) colony during a 15-year period. Clinical histories of 565 female baboons with one or more fetal losses during a 20-year period were analyzed for weight, age, and reproductive history. Results: Fetal loss was most common at term (35.57%) and preterm (28.61%) and less common in the first half of gestation (11.20%) and post-term (5.22%). Greater maternal weight, older age, history of stillbirth and higher parity were independent predictors for stillbirth. An exponential increase in the incidence of fetal loss was observed beginning at age 14years in baboons. Conclusions: Fetal loss and maternal risk factors associated with stillbirths in baboons were similar to those documented in women.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalJournal of medical primatology
Volume37
Issue number6
DOIs
Publication statusPublished - Nov 11 2008

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Keywords

  • Animal model
  • Epidemiology
  • Fetal loss
  • Nonhuman primates
  • Reproduction

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Schlabritz-Loutsevitch, N. E., Moore, C. M., Lopez-Alvarenga, J. C., Dunn, B. G., Dudley, D., & Hubbard, G. B. (2008). The baboon model (Papio hamadryas) of fetal loss: Maternal weight, age, reproductive history and pregnancy outcome. Journal of medical primatology, 37(6), 337-345. https://doi.org/10.1111/j.1600-0684.2008.00297.x