TY - JOUR
T1 - The baboon in epilepsy research
T2 - Revelations and challenges
AU - Szabó, C. Ákos
AU - Salinas, Felipe S.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/8
Y1 - 2021/8
N2 - The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).
AB - The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).
KW - Baboon
KW - Electrophysiology
KW - Genetic generalized epilepsy
KW - Neuroimaging
KW - Neurostimulation
KW - Seizure detection
UR - http://www.scopus.com/inward/record.url?scp=85107817111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107817111&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2021.108012
DO - 10.1016/j.yebeh.2021.108012
M3 - Review article
C2 - 34022622
AN - SCOPUS:85107817111
SN - 1525-5050
VL - 121
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 108012
ER -