TY - JOUR
T1 - The baboon in epilepsy research
T2 - Revelations and challenges
AU - Szabó, C. Ákos
AU - Salinas, Felipe S.
N1 - Funding Information:
CÁS: Studies were supported by NIH/NINDS ( R01 NS047755 , R21 NS065431 , and R21 NS084198 ), NIH/NCRR ( P51 RR013986 ), and NIH/ORIP ( P51 OD011133 ), and conducted in facilities constructed with support from Research Facilities Improvement Grants C06 RR013556, C06 RR014578, and C06 RR015456. FSS: Funding for studies performed within the scope of this review came from a Ruth L. Kirschstein National Research Service Award from the National Institute of Neurological Disorders and Stroke , United States ( NIH/NINDS F32 NS066694 ). Additional funding for this research came from the NIH/NINDS R21 NS062254.
Funding Information:
C?S: Studies were supported by NIH/NINDS (R01 NS047755, R21 NS065431, and R21 NS084198), NIH/NCRR (P51 RR013986), and NIH/ORIP (P51 OD011133), and conducted in facilities constructed with support from Research Facilities Improvement Grants C06 RR013556, C06 RR014578, and C06 RR015456. FSS: Funding for studies performed within the scope of this review came from a Ruth L. Kirschstein National Research Service Award from the National Institute of Neurological Disorders and Stroke, United States (NIH/NINDS F32 NS066694). Additional funding for this research came from the NIH/NINDS R21 NS062254. The authors have nothing to declare. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with these guidelines.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/8
Y1 - 2021/8
N2 - The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).
AB - The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).
KW - Baboon
KW - Electrophysiology
KW - Genetic generalized epilepsy
KW - Neuroimaging
KW - Neurostimulation
KW - Seizure detection
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U2 - 10.1016/j.yebeh.2021.108012
DO - 10.1016/j.yebeh.2021.108012
M3 - Review article
C2 - 34022622
AN - SCOPUS:85107817111
SN - 1525-5050
VL - 121
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 108012
ER -