The baboon as a nonhuman primate model for the study of the genetics of obesity

Anthony G. Comuzzie, Shelley A. Cole, Lisa Martin, K. Dee Carey, Michael C. Mahaney, John Blangero, John L. VandeBerg

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective: At present, rodents represent the most common animal model for research in obesity and its comorbidities (e.g., type 2 diabetes and coronary heart disease), however, there are several physiological and developmental differences between rodents and humans reflective of their relatively ancient evolutionary divergence (approximately 65 to 75 million years ago). Therefore, we are currently developing the baboon as a nonhuman primate model for the study of the genetics of obesity. Research Methods and Procedures: At present, we are collecting extensive phenotypic data in a large pedigreed colony (N > 2000) of baboons housed at the Southwest Foundation for Biomedical Research in San Antonio, Texas. The long-term goal of this project is to identify genes influencing adiposity-related phenotypes and to test hypotheses regarding their pleiotropic effects on other phenotypes related to increased risk for a variety of common diseases (e.g., coronary heart disease and type 2 diabetes). Results: To date we have obtained various adipose-specific endocrine measures, adipose tissue biopsies, and estimates of body composition on a substantial portion of our pedigreed colony. The pattern of adipose tissue accumulation follows closely that seen in humans, and we have detected significant additive genetic heritabilities for these obesity-related phenotypes. Discussion: Given the physiological and developmental similarities between humans and baboons, along with the ability to collect data under well-controlled situations and the extensive pedigree data available in our colony, the baboon offers an extremely valuable nonhuman primate model for the study of obesity and its comorbidities.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalObesity Research
Volume11
Issue number1
StatePublished - 2003
Externally publishedYes

Fingerprint

Papio
Genetic Models
Primates
obesity
Obesity
animal models
Phenotype
noninsulin-dependent diabetes mellitus
phenotype
Type 2 Diabetes Mellitus
adipose tissue
Coronary Disease
Adipose Tissue
Comorbidity
Rodentia
rodents
divergent evolution
biomedical research
Adiposity
adiposity

Keywords

  • Animal model
  • Body composition
  • Heritabilities
  • Pedigreed colony

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Comuzzie, A. G., Cole, S. A., Martin, L., Carey, K. D., Mahaney, M. C., Blangero, J., & VandeBerg, J. L. (2003). The baboon as a nonhuman primate model for the study of the genetics of obesity. Obesity Research, 11(1), 75-80.

The baboon as a nonhuman primate model for the study of the genetics of obesity. / Comuzzie, Anthony G.; Cole, Shelley A.; Martin, Lisa; Carey, K. Dee; Mahaney, Michael C.; Blangero, John; VandeBerg, John L.

In: Obesity Research, Vol. 11, No. 1, 2003, p. 75-80.

Research output: Contribution to journalArticle

Comuzzie, AG, Cole, SA, Martin, L, Carey, KD, Mahaney, MC, Blangero, J & VandeBerg, JL 2003, 'The baboon as a nonhuman primate model for the study of the genetics of obesity', Obesity Research, vol. 11, no. 1, pp. 75-80.
Comuzzie AG, Cole SA, Martin L, Carey KD, Mahaney MC, Blangero J et al. The baboon as a nonhuman primate model for the study of the genetics of obesity. Obesity Research. 2003;11(1):75-80.
Comuzzie, Anthony G. ; Cole, Shelley A. ; Martin, Lisa ; Carey, K. Dee ; Mahaney, Michael C. ; Blangero, John ; VandeBerg, John L. / The baboon as a nonhuman primate model for the study of the genetics of obesity. In: Obesity Research. 2003 ; Vol. 11, No. 1. pp. 75-80.
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