The association of the MYH9 gene and kidney outcomes in American Indians: The Strong Heart Family Study

Nora Franceschini, V. Saroja Voruganti, Karin Haack, Laura Almasy, Sandy Laston, Harald H H Göring, Jason G. Umans, Elisa T. Lee, Lyle G. Best, Richard R. Fabsitz, Jean W. MacCluer, Barbara V. Howard, Kari E. North, Shelley A. Cole

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans. Whether these associations are also present among American Indian individuals is unknown. To evaluate the role of genetic polymorphisms in the MYH9 gene on kidney disease in American Indians, we genotyped 25 SNPs in the MYH9 gene region in 1,119 comparatively unrelated individuals. Four SNPs failed, and one SNP was monomorphic. We inferred haplotypes using seven SNPs within the region of the previously described E haplotype using Phase v2.1. We studied the association between 20 MYH9 SNPs with kidney function (estimated glomerular filtration rate, eGFR) and CKD (eGFR < 60 ml/min/1.73 m2 or renal replacement therapy or kidney transplant) using age-, sex- and center-adjusted models and measured genotyped within the variance component models. MYH9 SNPs were not significantly associated with kidney traits in additive or recessive genetic adjusted models. MYH9 haplotypes were also not significantly associated with kidney outcomes. In conclusion, common variants in MYH9 polymorphisms may not confer an increased risk of CKD in American Indian populations. Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalHuman Genetics
Volume127
Issue number3
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

North American Indians
Single Nucleotide Polymorphism
Chronic Renal Insufficiency
Kidney
Haplotypes
Genes
Glomerular Filtration Rate
African Americans
Population
Renal Replacement Therapy
Myosin Heavy Chains
Genetic Models
Kidney Diseases
Genetic Polymorphisms
Protein Isoforms
Public Health
Transplants
Research

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Franceschini, N., Voruganti, V. S., Haack, K., Almasy, L., Laston, S., Göring, H. H. H., ... Cole, S. A. (2010). The association of the MYH9 gene and kidney outcomes in American Indians: The Strong Heart Family Study. Human Genetics, 127(3), 295-301. https://doi.org/10.1007/s00439-009-0769-8

The association of the MYH9 gene and kidney outcomes in American Indians : The Strong Heart Family Study. / Franceschini, Nora; Voruganti, V. Saroja; Haack, Karin; Almasy, Laura; Laston, Sandy; Göring, Harald H H; Umans, Jason G.; Lee, Elisa T.; Best, Lyle G.; Fabsitz, Richard R.; MacCluer, Jean W.; Howard, Barbara V.; North, Kari E.; Cole, Shelley A.

In: Human Genetics, Vol. 127, No. 3, 2010, p. 295-301.

Research output: Contribution to journalArticle

Franceschini, N, Voruganti, VS, Haack, K, Almasy, L, Laston, S, Göring, HHH, Umans, JG, Lee, ET, Best, LG, Fabsitz, RR, MacCluer, JW, Howard, BV, North, KE & Cole, SA 2010, 'The association of the MYH9 gene and kidney outcomes in American Indians: The Strong Heart Family Study', Human Genetics, vol. 127, no. 3, pp. 295-301. https://doi.org/10.1007/s00439-009-0769-8
Franceschini, Nora ; Voruganti, V. Saroja ; Haack, Karin ; Almasy, Laura ; Laston, Sandy ; Göring, Harald H H ; Umans, Jason G. ; Lee, Elisa T. ; Best, Lyle G. ; Fabsitz, Richard R. ; MacCluer, Jean W. ; Howard, Barbara V. ; North, Kari E. ; Cole, Shelley A. / The association of the MYH9 gene and kidney outcomes in American Indians : The Strong Heart Family Study. In: Human Genetics. 2010 ; Vol. 127, No. 3. pp. 295-301.
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