The association of endothelial function and tone by digital arterial tonometry with MRI left ventricular mass in African Americans: the Jackson Heart Study

Avnish Tripathi, Emelia J. Benjamin, Solomon K. Musani, Naomi M. Hamburg, Connie W. Tsao, Arti Saraswat, Ramachandran S. Vasan, Gary F. Mitchell, Ervin R. Fox

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Peripheral vascular endothelial dysfunction assessed by digital peripheral arterial tonometry (PAT) has been associated with risk for adverse cardiovascular events. We examined the relations of peripheral microvascular dysfunction and left ventricular mass in a community-based cohort of African Americans. We examined participants of the Jackson Heart Study who had PAT and cardiac magnetic resonance imaging evaluations between 2007 and 2013. Consistent with pertinent literature, left ventricular mass index (LVMI) was adjusted for body size by indexing to height2.7. Pearson's correlation and general linear regression analyses were used to relate reactive hyperemia index, baseline pulse amplitude (BPA), and augmentation index (markers of microvascular vasodilator function, baseline vascular pulsatility, and relative wave reflection, respectively) to LVMI after adjusting for traditional cardiovascular risk factors. A total of 440 participants (mean age 59 ± 10 years, 60% women) were included. Age- and sex-adjusted Pearson's correlation analysis suggested that natural log transformed LVMI was negatively correlated with reactive hyperemia index (coefficient: −0.114; P =.02) and positively correlated with BPA (coefficient: 0.272; P <.001). In multivariable analyses, higher loge LVMI was associated with higher BPA (β: 0.210; P =.03) after accounting for age, sex, body mass index, diabetes, hypertension, ratio of total cholesterol and high-density lipoprotein cholesterol, smoking, and history of cardiovascular disease. In a community-based sample of African Americans, higher baseline pulsatility measured by PAT was associated with higher LVMI by cardiac magnetic resonance imaging after adjusting for traditional risk factors.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalJournal of the American Society of Hypertension
Volume11
Issue number5
DOIs
StatePublished - May 2017
Externally publishedYes

Keywords

  • Augmentation index
  • baseline pulse amplitude
  • reactive hyperemia index
  • sub-clinical cardiovascular risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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