@article{0517262e547c4a519d4cfc05be46533c,
title = "The association of body mass index and prostate-specific antigen in a population-based study",
abstract = "BACKGROUND. Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS. The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS. The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS. Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma.",
keywords = "Body mass index, Cancer risk, Prostate carcinoma, Prostate-specific antigen",
author = "Jacques Baillargeon and Pollock, {Brad H.} and Kristal, {Alan R.} and Patrick Bradshaw and Javier Hernandez and Joseph Basler and Betsy Higgins and Steve Lynch and Thomas Rozanski and Dean Troyer and Ian Thompson",
note = "Funding Information: Patrick C. Walsh M.D. The Association of Body Mass Index and Prostate-Specific Antigen in a Population-Based Study J. Baillargeon, B. H. Pollock, A. R. Kristal, P. Bradshaw, J. Hernandez, J. Basler, B. Higgins, S. Lynch, T. Rozanski, D. Troyer and I. Thompson, Center for Epidemiology and Biostatistics, and Departments of Pediatrics, Surgery and Pathology, University of Texas Health Science Center and Departments of Surgery, Wilford Hall Medical Center and Brooke Army Medical Center, San Antonio, Texas, and Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington Cancer, 103: 1092–1095, 2005 BACKGROUND. Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS. The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS. The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS. Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma. ",
year = "2005",
month = mar,
day = "1",
doi = "10.1002/cncr.20856",
language = "English (US)",
volume = "103",
pages = "1092--1095",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",
}