The application of positron emission tomography to the study of panic disorder

E. M. Reiman, M. E. Raichle, E. Robins, F. K. Butler, P. Herscovitch, P. Fox, J. Perlmutter

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections is proposed.

Original languageEnglish (US)
Pages (from-to)469-477
Number of pages9
JournalAmerican Journal of Psychiatry
Volume143
Issue number4
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'The application of positron emission tomography to the study of panic disorder'. Together they form a unique fingerprint.

Cite this