The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes

Nu Zhang, You Wen He

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The antiapoptotic protein Bcl-xL is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. Bcl-xL is also highly enriched in memory T lymphocytes. Based on this body of evidence, it was thought that Bcl-xL plays an essential role in the generation of effector and memory T lymphocytes. We report that mice with a conditional deletion of Bcl-x in T lymphocytes develop a normal CD8+ T cell response to Listeria monocytogenes infection. Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent humoral immune responses. These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-xL independent mechanism.

Original languageEnglish (US)
Pages (from-to)6967-6973
Number of pages7
JournalJournal of Immunology
Volume174
Issue number11
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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