The anti-ageing action of dietary restriction

Holly Van Remmen, Zhongmao Guo, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Over 60 years ago, McCay's laboratory showed that dietary or calorie-restriction dramatically increased the lifespan of rats. Since then, numerous laboratories with a variety of strains of rats and mice have confirmed this initial observation and have shown that reducing calorie intake (without malnutrition) significantly increases both the mean and maximum survival of rodents. Currently, dietary restriction is the only experimental manipulation that has been shown to retard ageing of mammals. Although mechanism whereby dietary restriction retards ageing is currently unknown, much of the emerging data suggest that the calorie-restricted rodents live longer and age more slowly because they are more resistant to stress and have an enhanced ability to protect cells against damaging agents.

Original languageEnglish (US)
Pages (from-to)221-233
Number of pages13
JournalNovartis Foundation Symposium
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'The anti-ageing action of dietary restriction'. Together they form a unique fingerprint.

Cite this