The analysis of dose‐response curves‐a practical approach.

SH Jackson; MJ Jamieson; A. Johnston; AM Shepherd

doi:10.1111/j.1365-2125.1987.tb03030.x

The analysis of dose‐response curves‐a practical approach.

SH Jackson, MJ Jamieson, A. Johnston, AM Shepherd

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The rationale for the objective assessment of dose‐response curves (DRCs) is presented. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. A parallel shift Emax model is proposed for complete DRCs. 1987 The British Pharmacological Society

Original language	English (US)
Pages (from-to)	199-205
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2125.1987.tb03030.x
State	Published - Feb 1987
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

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10.1111/j.1365-2125.1987.tb03030.x

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The analysis of dose‐response curves‐a practical approach.

Abstract

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