The analysis of dose‐response curves‐a practical approach.

SH Jackson, MJ Jamieson, A. Johnston, AM Shepherd

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The rationale for the objective assessment of dose‐response curves (DRCs) is presented. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. A parallel shift Emax model is proposed for complete DRCs. 1987 The British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume23
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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