The analysis of dose-response curves - A practical approach

S. H D Jackson, M. J. Jamieson, A. Johnston, Alexander M Shepherd

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. The rationale for the objective assessment of dose-response curves (DRCs) is presented. 2. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. 3. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. 4. A parallel shift E(max) model is proposed for complete DRCs.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume23
Issue number2
StatePublished - 1987
Externally publishedYes

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Blood Pressure
Phenylephrine
Isoproterenol
Heart Rate
Datasets

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Jackson, S. H. D., Jamieson, M. J., Johnston, A., & Shepherd, A. M. (1987). The analysis of dose-response curves - A practical approach. British Journal of Clinical Pharmacology, 23(2), 199-205.

The analysis of dose-response curves - A practical approach. / Jackson, S. H D; Jamieson, M. J.; Johnston, A.; Shepherd, Alexander M.

In: British Journal of Clinical Pharmacology, Vol. 23, No. 2, 1987, p. 199-205.

Research output: Contribution to journalArticle

Jackson, SHD, Jamieson, MJ, Johnston, A & Shepherd, AM 1987, 'The analysis of dose-response curves - A practical approach', British Journal of Clinical Pharmacology, vol. 23, no. 2, pp. 199-205.
Jackson SHD, Jamieson MJ, Johnston A, Shepherd AM. The analysis of dose-response curves - A practical approach. British Journal of Clinical Pharmacology. 1987;23(2):199-205.
Jackson, S. H D ; Jamieson, M. J. ; Johnston, A. ; Shepherd, Alexander M. / The analysis of dose-response curves - A practical approach. In: British Journal of Clinical Pharmacology. 1987 ; Vol. 23, No. 2. pp. 199-205.
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