The acquisition of human lactoferrin by Mycoplasma pneumoniae

Victor V. Tryon, Joel B. Baseman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We tested the in vitro binding of human iron-sequestering lactoferrin and transferrin by the mucosal-surface pathogens, Mycoplasma pneumoniae and Mycoplasma genitalium. Mycoplasma pneumoniae bound lactoferrin, but not transferrin, in a saturable and specific manner. Analysis of binding data indicates less than 10000 lactoferrin receptors per micro-organism with a moderately high binding affinity of 20 nm. No significant binding of lactoferrin or transferrin by M. genitalium was observed.

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalMicrobial Pathogenesis
Volume3
Issue number6
DOIs
StatePublished - Dec 1987

Keywords

  • Mycoplasma
  • lactoferrin
  • transferrin

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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