TY - JOUR
T1 - The -56T HLA-G promoter polymorphism is not associated with pre-eclampsia/eclampsia in Australian and New Zealand women
AU - Doherty, Vicki
AU - Rush, Ashley
AU - Brennecke, Shaun
AU - Moses, Eric
N1 - Funding Information:
The authors gratefully acknowledge the assistance of clinical research midwives Tracey Nielsen, Moira Stewart, and Sandy Walker in patient ascertainment, recruitment, and sampling and all the women and their families who participated in this study. This work was supported by Australian National Health and Medical Research Council project grant 970589, the University of Melbourne, the Royal Women’s Hospital Melbourne, and Wake Forest University, Winston-Salem, NC, USA.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - Objective: Decreased HLA-G expression has been linked to a number of pregnancy disorders, including preeclampsia, and a genetic basis for HLA-G regulation has yet to be found. The aim of this study was to determine whether a C-to-T base substitution 56 base pairs (bp) upstream from the HLA-G transcription start site is associated with preeclampsia. Methods: 277 nulliparous women consisting of 113 normotensive, 118 preeclamptic, and 46 eclamptic patients were typed for the -56T polymorphism using restriction fragment length polymorphism and allelic discrimination analysis. Results: -56T allele frequencies for eclamptic, preeclamptic, and normotensive women were 0.053, 0.030, and 0.035, respectively. A χ 2 test indicated that there was no significant association with the polymorphism in preeclamptic or eclamptic women with p > 0.05. Conclusion: The -56T HLA-G polymorphism is not associated with preeclampsia or eclampsia in our population.
AB - Objective: Decreased HLA-G expression has been linked to a number of pregnancy disorders, including preeclampsia, and a genetic basis for HLA-G regulation has yet to be found. The aim of this study was to determine whether a C-to-T base substitution 56 base pairs (bp) upstream from the HLA-G transcription start site is associated with preeclampsia. Methods: 277 nulliparous women consisting of 113 normotensive, 118 preeclamptic, and 46 eclamptic patients were typed for the -56T polymorphism using restriction fragment length polymorphism and allelic discrimination analysis. Results: -56T allele frequencies for eclamptic, preeclamptic, and normotensive women were 0.053, 0.030, and 0.035, respectively. A χ 2 test indicated that there was no significant association with the polymorphism in preeclamptic or eclamptic women with p > 0.05. Conclusion: The -56T HLA-G polymorphism is not associated with preeclampsia or eclampsia in our population.
KW - Allelic discrimination
KW - HLA-G
KW - Pre-eclampsia
KW - Promoter polymorphism
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U2 - 10.1080/10641950500543780
DO - 10.1080/10641950500543780
M3 - Article
C2 - 16867913
AN - SCOPUS:33746826041
VL - 25
SP - 63
EP - 71
JO - Hypertension in Pregnancy
JF - Hypertension in Pregnancy
SN - 1064-1955
IS - 2
ER -