The 40-year history of modeling active dendrites in cerebellar purkinje cells: Emergence of the first single cell “community model”

James M. Bower

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The subject of the effects of the active properties of the Purkinje cell dendrite on neuronal function has been an active subject of study for more than 40 years. Somewhat unusually, some of these investigations, from the outset have involved an interacting combination of experimental and model-based techniques. This article recounts that 40-year history, and the view of the functional significance of the active properties of the Purkinje cell dendrite that has emerged. It specifically considers the emergence from these efforts of what is arguably the first single cell “community” model in neuroscience. The article also considers the implications of the development of this model for future studies of the complex properties of neuronal dendrites.

Original languageEnglish (US)
Article number129
JournalFrontiers in Computational Neuroscience
Volume9
Issue numberOCTOBER
DOIs
StatePublished - Oct 20 2015
Externally publishedYes

Fingerprint

Purkinje Cells
Dendrites
History
Neurosciences
Theoretical Models

Keywords

  • Active conductnaces
  • Cerebellar
  • Cerebellum
  • Dendrite
  • History
  • Modeling
  • Purkinje cells

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

Cite this

The 40-year history of modeling active dendrites in cerebellar purkinje cells : Emergence of the first single cell “community model”. / Bower, James M.

In: Frontiers in Computational Neuroscience, Vol. 9, No. OCTOBER, 129, 20.10.2015.

Research output: Contribution to journalReview article

@article{9f36eb2e535c4e0fbda78a78c546163e,
title = "The 40-year history of modeling active dendrites in cerebellar purkinje cells: Emergence of the first single cell “community model”",
abstract = "The subject of the effects of the active properties of the Purkinje cell dendrite on neuronal function has been an active subject of study for more than 40 years. Somewhat unusually, some of these investigations, from the outset have involved an interacting combination of experimental and model-based techniques. This article recounts that 40-year history, and the view of the functional significance of the active properties of the Purkinje cell dendrite that has emerged. It specifically considers the emergence from these efforts of what is arguably the first single cell “community” model in neuroscience. The article also considers the implications of the development of this model for future studies of the complex properties of neuronal dendrites.",
keywords = "Active conductnaces, Cerebellar, Cerebellum, Dendrite, History, Modeling, Purkinje cells",
author = "Bower, {James M.}",
year = "2015",
month = "10",
day = "20",
doi = "10.3389/fncom.2015.00129",
language = "English (US)",
volume = "9",
journal = "Frontiers in Computational Neuroscience",
issn = "1662-5188",
publisher = "Frontiers Research Foundation",
number = "OCTOBER",

}

TY - JOUR

T1 - The 40-year history of modeling active dendrites in cerebellar purkinje cells

T2 - Emergence of the first single cell “community model”

AU - Bower, James M.

PY - 2015/10/20

Y1 - 2015/10/20

N2 - The subject of the effects of the active properties of the Purkinje cell dendrite on neuronal function has been an active subject of study for more than 40 years. Somewhat unusually, some of these investigations, from the outset have involved an interacting combination of experimental and model-based techniques. This article recounts that 40-year history, and the view of the functional significance of the active properties of the Purkinje cell dendrite that has emerged. It specifically considers the emergence from these efforts of what is arguably the first single cell “community” model in neuroscience. The article also considers the implications of the development of this model for future studies of the complex properties of neuronal dendrites.

AB - The subject of the effects of the active properties of the Purkinje cell dendrite on neuronal function has been an active subject of study for more than 40 years. Somewhat unusually, some of these investigations, from the outset have involved an interacting combination of experimental and model-based techniques. This article recounts that 40-year history, and the view of the functional significance of the active properties of the Purkinje cell dendrite that has emerged. It specifically considers the emergence from these efforts of what is arguably the first single cell “community” model in neuroscience. The article also considers the implications of the development of this model for future studies of the complex properties of neuronal dendrites.

KW - Active conductnaces

KW - Cerebellar

KW - Cerebellum

KW - Dendrite

KW - History

KW - Modeling

KW - Purkinje cells

UR - http://www.scopus.com/inward/record.url?scp=84948753844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948753844&partnerID=8YFLogxK

U2 - 10.3389/fncom.2015.00129

DO - 10.3389/fncom.2015.00129

M3 - Review article

AN - SCOPUS:84948753844

VL - 9

JO - Frontiers in Computational Neuroscience

JF - Frontiers in Computational Neuroscience

SN - 1662-5188

IS - OCTOBER

M1 - 129

ER -