Abstract
OBJECTIVE: To examine the role of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and the β3-adrenergic receptor gene locus in obesity-related traits in African Americans. SUBJECTS: A total of 687 individuals representing 193 African American families who were residents of metropolitan Chicago. MEASUREMENTS: Genotyping of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and three microsatellite markers flanking the β3-adrenergic receptor gene (ADRB3) locus and measuring various obesity-related traits, including body mass index (BMI), fat-free mass, fat mass, percentage fat mass, waist circumference and serum lipid levels. RESULTS: The prevalence of obesity (defined as body mass index ≥30 kg/m2) in the population was 27.3% and 51.2% in men and women, respectively. The frequency of the Arg64 allele was 10.0%. Multivariate regression analyses confirmed the existence of a significant contribution of familial variance to each of the five obesity-related traits noted above. Likelihood ratio statistics computed in a multivariate regression analysis failed to demonstrate a significant association between the Arg64 allele and any of the five obesity-related traits. Single and multipoint analyses using extended Haseman-Elston regression analyses failed to demonstrate suggestive evidence of linkage of three microsatellite markers that flank the β3-adrenergic receptor gene to BMI, percentage body fat, waist circumference or serum leptin levels. CONCLUSION: Given the contribution of familial variance to obesity-related traits in this population, neither the null finding for the Arg64 allele nor the lack of evidence of linkage of the ADRB3 locus to obesity-related traits could be attributed to lack of transmissibility of the traits suggesting that neither the Arg64 variant of the β3-adrenergic receptor gene nor another genetic variant in or near the ADRB3 locus contribute significantly to familial aggregation of obesity-related traits in African Americans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 54-60 |
| Number of pages | 7 |
| Journal | International Journal of Obesity |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- β3-adrenergic receptor
- African American
- Genetics
- Leptin
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
The β3-adrenergic receptor gene and obesity in a population sample of African Americans. / Lowe, W. L.; Rotimi, C. N.; Luke, A.; Guo, X.; Zhu, X.; Comuzzie, A. G.; Schuh, T. S.; Halbach, S.; Kotlar, T. J.; Cooper, R. S.
In: International Journal of Obesity, Vol. 25, No. 1, 2001, p. 54-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The β3-adrenergic receptor gene and obesity in a population sample of African Americans
AU - Lowe, W. L.
AU - Rotimi, C. N.
AU - Luke, A.
AU - Guo, X.
AU - Zhu, X.
AU - Comuzzie, A. G.
AU - Schuh, T. S.
AU - Halbach, S.
AU - Kotlar, T. J.
AU - Cooper, R. S.
PY - 2001
Y1 - 2001
N2 - OBJECTIVE: To examine the role of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and the β3-adrenergic receptor gene locus in obesity-related traits in African Americans. SUBJECTS: A total of 687 individuals representing 193 African American families who were residents of metropolitan Chicago. MEASUREMENTS: Genotyping of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and three microsatellite markers flanking the β3-adrenergic receptor gene (ADRB3) locus and measuring various obesity-related traits, including body mass index (BMI), fat-free mass, fat mass, percentage fat mass, waist circumference and serum lipid levels. RESULTS: The prevalence of obesity (defined as body mass index ≥30 kg/m2) in the population was 27.3% and 51.2% in men and women, respectively. The frequency of the Arg64 allele was 10.0%. Multivariate regression analyses confirmed the existence of a significant contribution of familial variance to each of the five obesity-related traits noted above. Likelihood ratio statistics computed in a multivariate regression analysis failed to demonstrate a significant association between the Arg64 allele and any of the five obesity-related traits. Single and multipoint analyses using extended Haseman-Elston regression analyses failed to demonstrate suggestive evidence of linkage of three microsatellite markers that flank the β3-adrenergic receptor gene to BMI, percentage body fat, waist circumference or serum leptin levels. CONCLUSION: Given the contribution of familial variance to obesity-related traits in this population, neither the null finding for the Arg64 allele nor the lack of evidence of linkage of the ADRB3 locus to obesity-related traits could be attributed to lack of transmissibility of the traits suggesting that neither the Arg64 variant of the β3-adrenergic receptor gene nor another genetic variant in or near the ADRB3 locus contribute significantly to familial aggregation of obesity-related traits in African Americans.
AB - OBJECTIVE: To examine the role of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and the β3-adrenergic receptor gene locus in obesity-related traits in African Americans. SUBJECTS: A total of 687 individuals representing 193 African American families who were residents of metropolitan Chicago. MEASUREMENTS: Genotyping of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and three microsatellite markers flanking the β3-adrenergic receptor gene (ADRB3) locus and measuring various obesity-related traits, including body mass index (BMI), fat-free mass, fat mass, percentage fat mass, waist circumference and serum lipid levels. RESULTS: The prevalence of obesity (defined as body mass index ≥30 kg/m2) in the population was 27.3% and 51.2% in men and women, respectively. The frequency of the Arg64 allele was 10.0%. Multivariate regression analyses confirmed the existence of a significant contribution of familial variance to each of the five obesity-related traits noted above. Likelihood ratio statistics computed in a multivariate regression analysis failed to demonstrate a significant association between the Arg64 allele and any of the five obesity-related traits. Single and multipoint analyses using extended Haseman-Elston regression analyses failed to demonstrate suggestive evidence of linkage of three microsatellite markers that flank the β3-adrenergic receptor gene to BMI, percentage body fat, waist circumference or serum leptin levels. CONCLUSION: Given the contribution of familial variance to obesity-related traits in this population, neither the null finding for the Arg64 allele nor the lack of evidence of linkage of the ADRB3 locus to obesity-related traits could be attributed to lack of transmissibility of the traits suggesting that neither the Arg64 variant of the β3-adrenergic receptor gene nor another genetic variant in or near the ADRB3 locus contribute significantly to familial aggregation of obesity-related traits in African Americans.
KW - β3-adrenergic receptor
KW - African American
KW - Genetics
KW - Leptin
UR - http://www.scopus.com/inward/record.url?scp=17744391746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744391746&partnerID=8YFLogxK
U2 - 10.1038/sj.ijo.0801487
DO - 10.1038/sj.ijo.0801487
M3 - Article
C2 - 11244458
AN - SCOPUS:17744391746
VL - 25
SP - 54
EP - 60
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 1
ER -