TGF-β1 null mutation leads to CD154 upregulated expression in affected tissues

Toru Nakabayashi, Ken Mei Sakata, Atsuko Sakata, Liping Kong, C. Allen Lau, John J. Letterio, Norma Vela-Roch, Norman Talal, Howard Dang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The TGF-β1(-/-) mouse is a murine model for systemic autoimmune disease. The aim of this study is to elucidate the immunological mechanism that leads to multifocal tissue inflammation and autoantibody production in TGF-β1(-/-) mice. Heart, lung, liver, and salivary gland from TGF-β1(-/-) were assessed for CD154 expression by RT-PCR and immunohistochemistry. Compared to wild-type littermates, CD154 expression was elevated in all tissues studied. Furthermore, IL-12 mRNA was expressed in the salivary gland and heart of TGF-β1(-/-) mice and not in wild-type littermates. This suggests that the CD154 pathway is activated in these tissues. This shows that TGF-β1 regulates CD154 expression leading to spontaneous IL-12 production and autoimmunity.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalInflammation
Volume25
Issue number2
DOIs
StatePublished - 2001

Keywords

  • CD154
  • Interleukin (IL-12)
  • Tissue inflammation
  • Transforming growth factor (TGF-β1)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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