TGF-β1 Codon 10 T>C polymorphism influences short-term functional and cognitive decline in healthy oldest-old individuals: The pietà study

Vanessa G. Fraga, Henrique C. Guimarães, Vivian P. Lara, Antônio L. Teixeira, Maira T. Barbosa, Maria G. Carvalho, Paulo Caramelli, Karina B. Gomes

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Inflammation and cytokine production are a common finding in aging, which probably exert influence on cognitive and functional abilities in elderly people. Transforming-growth-factor beta 1 (TGF-β1) is an important multifunctional antiinflammatory cytokine that displays immunomodulatory activities. Objective: This prospective investigation aimed to evaluate the TGF-β1 codon 10 T>C on functional and cognitive decline in subjects aged 75+ years. Methods: The Functional Activities Questionnaire evaluated the functional performance and the cognitive assessment was evaluated through brief cognitive tests, consisting of: the Mini-Mental State Examination, animal category fluency test, and picture drawings memory test. All tests were administered twice, with a one-year interval. Results: Carriers of Tlower allele showed significant short-term decline in cognitive and functional performance, while individuals with CChigher genotype of TGF-β1 codon 10 T>C remained stable or showed improvement. Conclusion: Our findings indicate that the lower production of TGF-β1 could predict a longitudinal functional and cognitive decline in oldest-old individuals.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalJournal of Alzheimer's Disease
Volume48
Issue number4
DOIs
StatePublished - Oct 27 2015
Externally publishedYes

Keywords

  • Aging
  • cognition
  • functional performance
  • polymorphism
  • TGF-β1

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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