TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation

Chaoyu Ma, Shruti Mishra, Erika L. Demel, Yong Liu, Zhang Nu

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Tissue-resident memory T (TRM) cells, a population of noncirculating memory T cells, are one of the essential components of immunological memory in both mouse and human. Although CD69+CD103+ TRM cells represent a major TRM cell population in barrier tissues including the mucosal surface and the skin, CD69+CD1032 TRM cells dominate most nonbarrier tissues, such as the kidney. TGF-β is required for the differentiation of CD69+CD103+ TRM cells in barrier tissues. However, the developmental control of CD69+CD1032 TRM cells in nonbarrier tissues remains largely unknown and the involvement of TGF-β signaling is less clear. In this study we demonstrated that TGF-β promoted the formation of kidney-resident T cells via enhancing the tissue entry of effector T cells. Mechanistically, TGF-β enhanced E- and P-selectin and inflammatory chemokine-mediated extravasation of effector T cells. Thus TGF-β controls the first developmental checkpoint of TRM cell differentiation in nonbarrier tissues.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalJournal of Immunology
Volume198
Issue number2
DOIs
StatePublished - Jan 15 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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