TGF-β and Eomes control the homeostasis of CD8+regulatory T cells

Shruti Mishra, Wei Liao, Yong Liu, Ming Yang, Chaoyu Ma, Haijing Wu, Ming Zhao, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.

Original languageEnglish (US)
Article numbere20200030
JournalJournal of Experimental Medicine
Volume218
Issue number1
DOIs
StatePublished - Jan 4 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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