TY - JOUR
T1 - TGF-β and Eomes control the homeostasis of CD8+regulatory T cells
AU - Mishra, Shruti
AU - Liao, Wei
AU - Liu, Yong
AU - Yang, Ming
AU - Ma, Chaoyu
AU - Wu, Haijing
AU - Zhao, Ming
AU - Zhang, Xin
AU - Qiu, Yuanzheng
AU - Lu, Qianjin
AU - Zhang, Nu
N1 - Publisher Copyright:
© 2020 Mishra et al.
PY - 2021/1/4
Y1 - 2021/1/4
N2 - In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.
AB - In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.
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U2 - 10.1084/JEM.20200030
DO - 10.1084/JEM.20200030
M3 - Article
C2 - 32991667
AN - SCOPUS:85092446737
SN - 0022-1007
VL - 218
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
M1 - e20200030
ER -