Tetrahydroaminoacridine antagonism to narcotic addiction

Maurice S. Albin; Malcolm D. Orr; Leonid Bunegin; Paul A. Henderson

doi:10.1016/0014-4886(75)90132-6

Tetrahydroaminoacridine antagonism to narcotic addiction

Maurice S. Albin, Malcolm D. Orr, Leonid Bunegin, Paul A. Henderson

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	644-648
Number of pages	5
Journal	Experimental Neurology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(75)90132-6
State	Published - Mar 1975
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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@article{9637d37e6950401dae9882174d6a1315,

title = "Tetrahydroaminoacridine antagonism to narcotic addiction",

author = "Albin, {Maurice S.} and Orr, {Malcolm D.} and Leonid Bunegin and Henderson, {Paul A.}",

note = "Funding Information: Tetrahydroaminoacridine (THA ; Tacrine ; 1,2,3,4-tetrahydro-S-aminoacridine) is a potent cholinesterase inhibitor (6) that has mild neuromuscular blocking action and has been used in man to reverse psychotic episodes precipitated by some anticholinergic psychotomimetics (4, 5, 7). Animal studies have suggested its effectiveness in reducing both sleep (anesthesia) time and postanesthetic emergence delirium following phencyclidine (1, 2) [l-( 1 phenyl cyclohex) piperidine hydrochloride] (22). The incidence of postanesthetic behavioral side effects following ketamine hydrochloride (11, 12, 14, 15, 23, 24) was markedly reduced in animal (1, 2) and human subjects (3) following THA dosing. Morphine antagonism by THA has been reported in a number of animal speciesa nd in man (8, 9, 13, N-20) ; this has consisted of rapid arousal, respiratory stimulation, decrease in euphoria, and no inhibition of the cough reflex. A study by Stone, Moon and Shaw (21) involving the treatment of intractable pain with morphine and THA indicated attenuation of physical dependence. They state in their conclusions that THA “is a partial antagonist to the narcotic analgesics, enabling morphine to be given (10-100 mg q.i.d.) without producing narcosis or respiratory depression. The patient does not become addicted, and, though tolerance still develops, the dose of morphine may be reduced or withdrawn without withdrawal symptoms. An additional advantage of THA is that it is stable and can be combined in the same 1 This investigation was supported in part by a grant from the Alcoa Foundation. Please address all correspondence to Dr. Maurice S. Albin. We thank Antoinette Perry for all her help. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1975",

month = mar,

doi = "10.1016/0014-4886(75)90132-6",

language = "English (US)",

volume = "46",

pages = "644--648",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Tetrahydroaminoacridine antagonism to narcotic addiction

AU - Albin, Maurice S.

AU - Orr, Malcolm D.

AU - Bunegin, Leonid

AU - Henderson, Paul A.

N1 - Funding Information: Tetrahydroaminoacridine (THA ; Tacrine ; 1,2,3,4-tetrahydro-S-aminoacridine) is a potent cholinesterase inhibitor (6) that has mild neuromuscular blocking action and has been used in man to reverse psychotic episodes precipitated by some anticholinergic psychotomimetics (4, 5, 7). Animal studies have suggested its effectiveness in reducing both sleep (anesthesia) time and postanesthetic emergence delirium following phencyclidine (1, 2) [l-( 1 phenyl cyclohex) piperidine hydrochloride] (22). The incidence of postanesthetic behavioral side effects following ketamine hydrochloride (11, 12, 14, 15, 23, 24) was markedly reduced in animal (1, 2) and human subjects (3) following THA dosing. Morphine antagonism by THA has been reported in a number of animal speciesa nd in man (8, 9, 13, N-20) ; this has consisted of rapid arousal, respiratory stimulation, decrease in euphoria, and no inhibition of the cough reflex. A study by Stone, Moon and Shaw (21) involving the treatment of intractable pain with morphine and THA indicated attenuation of physical dependence. They state in their conclusions that THA “is a partial antagonist to the narcotic analgesics, enabling morphine to be given (10-100 mg q.i.d.) without producing narcosis or respiratory depression. The patient does not become addicted, and, though tolerance still develops, the dose of morphine may be reduced or withdrawn without withdrawal symptoms. An additional advantage of THA is that it is stable and can be combined in the same 1 This investigation was supported in part by a grant from the Alcoa Foundation. Please address all correspondence to Dr. Maurice S. Albin. We thank Antoinette Perry for all her help. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1975/3

Y1 - 1975/3

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U2 - 10.1016/0014-4886(75)90132-6

DO - 10.1016/0014-4886(75)90132-6

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C2 - 1167514

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SP - 644

EP - 648

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 3

ER -

Tetrahydroaminoacridine antagonism to narcotic addiction

ASJC Scopus subject areas

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