Original language | English (US) |
---|---|
Pages (from-to) | 644-648 |
Number of pages | 5 |
Journal | Experimental Neurology |
Volume | 46 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
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Tetrahydroaminoacridine antagonism to narcotic addiction. / Albin, Maurice S.; Orr, Malcolm D.; Bunegin, Leonid et al.
In: Experimental Neurology, Vol. 46, No. 3, 03.1975, p. 644-648.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Tetrahydroaminoacridine antagonism to narcotic addiction
AU - Albin, Maurice S.
AU - Orr, Malcolm D.
AU - Bunegin, Leonid
AU - Henderson, Paul A.
N1 - Funding Information: Tetrahydroaminoacridine (THA ; Tacrine ; 1,2,3,4-tetrahydro-S-aminoacridine) is a potent cholinesterase inhibitor (6) that has mild neuromuscular blocking action and has been used in man to reverse psychotic episodes precipitated by some anticholinergic psychotomimetics (4, 5, 7). Animal studies have suggested its effectiveness in reducing both sleep (anesthesia) time and postanesthetic emergence delirium following phencyclidine (1, 2) [l-( 1 phenyl cyclohex) piperidine hydrochloride] (22). The incidence of postanesthetic behavioral side effects following ketamine hydrochloride (11, 12, 14, 15, 23, 24) was markedly reduced in animal (1, 2) and human subjects (3) following THA dosing. Morphine antagonism by THA has been reported in a number of animal speciesa nd in man (8, 9, 13, N-20) ; this has consisted of rapid arousal, respiratory stimulation, decrease in euphoria, and no inhibition of the cough reflex. A study by Stone, Moon and Shaw (21) involving the treatment of intractable pain with morphine and THA indicated attenuation of physical dependence. They state in their conclusions that THA “is a partial antagonist to the narcotic analgesics, enabling morphine to be given (10-100 mg q.i.d.) without producing narcosis or respiratory depression. The patient does not become addicted, and, though tolerance still develops, the dose of morphine may be reduced or withdrawn without withdrawal symptoms. An additional advantage of THA is that it is stable and can be combined in the same 1 This investigation was supported in part by a grant from the Alcoa Foundation. Please address all correspondence to Dr. Maurice S. Albin. We thank Antoinette Perry for all her help.
PY - 1975/3
Y1 - 1975/3
UR - http://www.scopus.com/inward/record.url?scp=0016634059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016634059&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(75)90132-6
DO - 10.1016/0014-4886(75)90132-6
M3 - Article
C2 - 1167514
AN - SCOPUS:0016634059
VL - 46
SP - 644
EP - 648
JO - Neurodegeneration
JF - Neurodegeneration
SN - 0014-4886
IS - 3
ER -