Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys

Lee Koetzner, Tina L. Sumpter, James H. Woods

Research output: Contribution to journalArticle

Abstract

For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume71
Issue number1-2
DOIs
StatePublished - Jan 2 2002
Externally publishedYes

Keywords

  • Cocaine
  • Operant suppression
  • Rhesus monkeys
  • Sodium channels
  • Tetrabenazine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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