Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys

Lee Koetzner; Tina L. Sumpter; James H. Woods

doi:10.1016/S0091-3057(01)00532-9

Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys

Lee Koetzner, Tina L. Sumpter, James H. Woods

Research output: Contribution to journal › Article › peer-review

Abstract

For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	71
Issue number	1-2
DOIs	https://doi.org/10.1016/S0091-3057(01)00532-9
State	Published - Jan 2 2002
Externally published	Yes

Keywords

Cocaine
Operant suppression
Rhesus monkeys
Sodium channels
Tetrabenazine

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/S0091-3057(01)00532-9

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abstract = "For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.",

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AU - Sumpter, Tina L.

AU - Woods, James H.

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N2 - For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.

AB - For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.

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KW - Rhesus monkeys

KW - Sodium channels

KW - Tetrabenazine

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Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys

Abstract

Keywords

ASJC Scopus subject areas

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