Testosterone replacement therapy and prostate cancer: A word of caution

Timothy C. Brand, Edith Canby-Hagino, Ian M. Thompson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The number of men for whom testosterone is prescribed is rapidly Increasing. The aging man normally demonstrates a gradual decline in testosterone. Symptoms of hypogonadism include erectile dysfunction, diminished libido, sarcopenia, increased adiposity, osteopenia and osteoporosis, impaired cognition, and depression. There is a paucity of data regarding both efficacy and safety of testosterone replacement therapy. Testosterone levels have been shown to modulate prostate cancer risk and progression. A prospective evaluation of prostate cancer risk with testosterone replacement therapy has not been conducted. We outline concerns and recommendations for the use of testosterone replacement therapy in the aging man.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalCurrent urology reports
Issue number3
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Urology


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