Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: The giant clam (Tridacna derasa)

Zoltan Ungvari, Anna Csiszar, Danuta Sosnowska, Eva E. Philipp, Courtney M. Campbell, Philip R. McQuary, Tracy T. Chow, Miguel Coelho, Elizabeth S. Didier, Sara Gelino, Marissa A. Holmbeck, Insil Kim, Erik Levy, William E. Sonntag, Paul W. Whitby, Steven N. Austad, Iain Ridgway

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropical long-lived sessile giant clam species, the smooth giant clam (Tridacna derasa; predicted maximum life span: >100 years) and the short-lived Atlantic bay scallop (Argopecten irradians irradians; maximum life span: 2 years). The warm water-dwelling giant clams warrant attention because they challenge the commonly held view that the exceptional longevity of bivalves is a consequence of the cold water they reside in. No significant interspecific differences in production of H2O2 and O2 - in the gills, heart, or adductor muscle were observed. Protein carbonyl content in gill and muscle tissues were similar in T derasa and A i irradians. In tissues of T derasa, neither basal antioxidant capacities nor superoxide dismutase and catalase activities were consistently greater than in A i irradians. We observed a positive association between longevity and resistance to mortality induced by exposure to tert-butyl hydroperoxide (TBHP). This finding is consistent with the prediction based on the oxidative stress hypothesis of aging. The findings that in tissues of T derasa, proteasome activities are significantly increased as compared with those in tissues of A i irradians warrant further studies to test the role of enhanced protein recycling activities in longevity of bivalves.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Evolution
  • Mollusc
  • Oxidative stress resistance
  • Oxidative stress theory
  • Senescence

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Ungvari, Z., Csiszar, A., Sosnowska, D., Philipp, E. E., Campbell, C. M., McQuary, P. R., Chow, T. T., Coelho, M., Didier, E. S., Gelino, S., Holmbeck, M. A., Kim, I., Levy, E., Sonntag, W. E., Whitby, P. W., Austad, S. N., & Ridgway, I. (2013). Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: The giant clam (Tridacna derasa). Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68(4), 359-367. https://doi.org/10.1093/gerona/gls159