TY - JOUR
T1 - Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity
T2 - The giant clam (Tridacna derasa)
AU - Ungvari, Zoltan
AU - Csiszar, Anna
AU - Sosnowska, Danuta
AU - Philipp, Eva E.
AU - Campbell, Courtney M.
AU - McQuary, Philip R.
AU - Chow, Tracy T.
AU - Coelho, Miguel
AU - Didier, Elizabeth S.
AU - Gelino, Sara
AU - Holmbeck, Marissa A.
AU - Kim, Insil
AU - Levy, Erik
AU - Sonntag, William E.
AU - Whitby, Paul W.
AU - Austad, Steven N.
AU - Ridgway, Iain
PY - 2013/4
Y1 - 2013/4
N2 - Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropical long-lived sessile giant clam species, the smooth giant clam (Tridacna derasa; predicted maximum life span: >100 years) and the short-lived Atlantic bay scallop (Argopecten irradians irradians; maximum life span: 2 years). The warm water-dwelling giant clams warrant attention because they challenge the commonly held view that the exceptional longevity of bivalves is a consequence of the cold water they reside in. No significant interspecific differences in production of H2O2 and O2 - in the gills, heart, or adductor muscle were observed. Protein carbonyl content in gill and muscle tissues were similar in T derasa and A i irradians. In tissues of T derasa, neither basal antioxidant capacities nor superoxide dismutase and catalase activities were consistently greater than in A i irradians. We observed a positive association between longevity and resistance to mortality induced by exposure to tert-butyl hydroperoxide (TBHP). This finding is consistent with the prediction based on the oxidative stress hypothesis of aging. The findings that in tissues of T derasa, proteasome activities are significantly increased as compared with those in tissues of A i irradians warrant further studies to test the role of enhanced protein recycling activities in longevity of bivalves.
AB - Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropical long-lived sessile giant clam species, the smooth giant clam (Tridacna derasa; predicted maximum life span: >100 years) and the short-lived Atlantic bay scallop (Argopecten irradians irradians; maximum life span: 2 years). The warm water-dwelling giant clams warrant attention because they challenge the commonly held view that the exceptional longevity of bivalves is a consequence of the cold water they reside in. No significant interspecific differences in production of H2O2 and O2 - in the gills, heart, or adductor muscle were observed. Protein carbonyl content in gill and muscle tissues were similar in T derasa and A i irradians. In tissues of T derasa, neither basal antioxidant capacities nor superoxide dismutase and catalase activities were consistently greater than in A i irradians. We observed a positive association between longevity and resistance to mortality induced by exposure to tert-butyl hydroperoxide (TBHP). This finding is consistent with the prediction based on the oxidative stress hypothesis of aging. The findings that in tissues of T derasa, proteasome activities are significantly increased as compared with those in tissues of A i irradians warrant further studies to test the role of enhanced protein recycling activities in longevity of bivalves.
KW - Evolution
KW - Mollusc
KW - Oxidative stress resistance
KW - Oxidative stress theory
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=84875175883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875175883&partnerID=8YFLogxK
U2 - 10.1093/gerona/gls159
DO - 10.1093/gerona/gls159
M3 - Article
C2 - 22904097
AN - SCOPUS:84875175883
VL - 68
SP - 359
EP - 367
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 4
ER -