Teratoma with trisomy 16 in a baboon (Papio hamadryas)

Charleen M. Moore, Jennifer Mckeand, Shelly M. Witte, Gene B. Hubbard, Jeffrey Rogers, M. Michelle Leland

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.

Original languageEnglish (US)
Pages (from-to)323-332
Number of pages10
JournalAmerican Journal of Primatology
Volume46
Issue number4
DOIs
StatePublished - 1998

Fingerprint

Papio hamadryas
trisomics
Papio
chromosome
chromosomes
Primates
primate
endopolyploidy
cesarean section
chromosome aberrations
sex chromosomes
ova
meiosis
chromosome number
genetic marker
abnormality
tumor
neoplasms
genetic markers

Keywords

  • Baboon
  • Teratoma
  • Trisomy

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Moore, C. M., Mckeand, J., Witte, S. M., Hubbard, G. B., Rogers, J., & Leland, M. M. (1998). Teratoma with trisomy 16 in a baboon (Papio hamadryas). American Journal of Primatology, 46(4), 323-332. https://doi.org/10.1002/(SICI)1098-2345(1998)46:4<323::AID-AJP4>3.0.CO;2-B

Teratoma with trisomy 16 in a baboon (Papio hamadryas). / Moore, Charleen M.; Mckeand, Jennifer; Witte, Shelly M.; Hubbard, Gene B.; Rogers, Jeffrey; Leland, M. Michelle.

In: American Journal of Primatology, Vol. 46, No. 4, 1998, p. 323-332.

Research output: Contribution to journalArticle

Moore, CM, Mckeand, J, Witte, SM, Hubbard, GB, Rogers, J & Leland, MM 1998, 'Teratoma with trisomy 16 in a baboon (Papio hamadryas)', American Journal of Primatology, vol. 46, no. 4, pp. 323-332. https://doi.org/10.1002/(SICI)1098-2345(1998)46:4<323::AID-AJP4>3.0.CO;2-B
Moore, Charleen M. ; Mckeand, Jennifer ; Witte, Shelly M. ; Hubbard, Gene B. ; Rogers, Jeffrey ; Leland, M. Michelle. / Teratoma with trisomy 16 in a baboon (Papio hamadryas). In: American Journal of Primatology. 1998 ; Vol. 46, No. 4. pp. 323-332.
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