Teratoma with trisomy 16 in a baboon (Papio hamadryas)

Charleen M. Moore; Jennifer Mckeand; Shelly M. Witte; Gene B. Hubbard; Jeffrey Rogers; M. Michelle Leland

doi:10.1002/(SICI)1098-2345(1998)46:4<323::AID-AJP4>3.0.CO;2-B

Teratoma with trisomy 16 in a baboon (Papio hamadryas)

Charleen M. Moore, Jennifer Mckeand, Shelly M. Witte, Gene B. Hubbard, Jeffrey Rogers, M. Michelle Leland

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.

Original language	English (US)
Pages (from-to)	323-332
Number of pages	10
Journal	American Journal of Primatology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1098-2345(1998)46:4<323::AID-AJP4>3.0.CO;2-B
State	Published - Dec 17 1998

Keywords

Baboon
Teratoma
Trisomy

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Animal Science and Zoology

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10.1002/(SICI)1098-2345(1998)46:4<323::AID-AJP4>3.0.CO;2-B

Cite this

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title = "Teratoma with trisomy 16 in a baboon (Papio hamadryas)",

abstract = "A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.",

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AU - Moore, Charleen M.

AU - Mckeand, Jennifer

AU - Witte, Shelly M.

AU - Hubbard, Gene B.

AU - Rogers, Jeffrey

AU - Leland, M. Michelle

PY - 1998/12/17

Y1 - 1998/12/17

N2 - A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.

AB - A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.

KW - Baboon

KW - Teratoma

KW - Trisomy

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Teratoma with trisomy 16 in a baboon (Papio hamadryas)

Abstract

Keywords

ASJC Scopus subject areas

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