Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons

Chih-ko Yeh, Gideon A. Rodan

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

An experimental system has been developed to examine the prostaglandin (PG) production induced by tensile mechanical forces in bone cells cultured on collagen ribbons. Fetal rat calvaria cells (osteoblast-enriched) were grown on collagen ribbons. The collagen ribbons were stretched under culture conditions in a machine that recorded force and displacement. Repeated stretching of the collagen ribbons (8 times, 5-10%, over 2 hours) increased the rate of prostaglandin synthesis approximately 3.5-fold over that of cells on nonstretched ribbons. This system should provide a suitable method to quantitatively study the effect of mechanical forces on various parameters of PG synthesis.

Original languageEnglish (US)
JournalCalcified Tissue International
Volume36
Issue number1 Supplement
DOIs
StatePublished - Mar 1984
Externally publishedYes

Fingerprint

Prostaglandins E
Collagen
Prostaglandins
Osteoblasts
Skull
Cultured Cells
Bone and Bones

Keywords

  • Bone cells
  • Mechanical force
  • Prostaglandins

ASJC Scopus subject areas

  • Endocrinology

Cite this

Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons. / Yeh, Chih-ko; Rodan, Gideon A.

In: Calcified Tissue International, Vol. 36, No. 1 Supplement, 03.1984.

Research output: Contribution to journalArticle

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