Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

Jared J. Luxton; Miles J. McKenna; Lynn E. Taylor; Kerry A. George; Sara R. Zwart; Brian E. Crucian; Viktor R. Drel; Francine E. Garrett-Bakelman; Matthew J. Mackay; Daniel Butler; Jonathan Foox; Kirill Grigorev; Daniela Bezdan; Cem Meydan; Scott M. Smith; Kumar Sharma; Christopher E. Mason; Susan M. Bailey

doi:10.1016/j.celrep.2020.108435

Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sara R. Zwart, Brian E. Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew J. Mackay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. Bailey

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.

Original language	English (US)
Article number	108435
Journal	Cell Reports
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.108435
State	Published - Dec 8 2020
Externally published	Yes

Keywords

DNA damage responses
ISS
International Space Station
NASA One-Year Mission
NASA Twins Study
space radiation environment
telomeres

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108435

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Luxton, J. J., McKenna, M. J., Taylor, L. E., George, K. A., Zwart, S. R., Crucian, B. E., Drel, V. R., Garrett-Bakelman, F. E., Mackay, M. J., Butler, D., Foox, J., Grigorev, K., Bezdan, D., Meydan, C., Smith, S. M., Sharma, K., Mason, C. E., & Bailey, S. M. (2020). Temporal Telomere and DNA Damage Responses in the Space Radiation Environment. Cell Reports, 33(10), Article 108435. https://doi.org/10.1016/j.celrep.2020.108435

Luxton, JJ, McKenna, MJ, Taylor, LE, George, KA, Zwart, SR, Crucian, BE, Drel, VR, Garrett-Bakelman, FE, Mackay, MJ, Butler, D, Foox, J, Grigorev, K, Bezdan, D, Meydan, C, Smith, SM, Sharma, K, Mason, CE & Bailey, SM 2020, 'Temporal Telomere and DNA Damage Responses in the Space Radiation Environment', Cell Reports, vol. 33, no. 10, 108435. https://doi.org/10.1016/j.celrep.2020.108435

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abstract = "Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.",

keywords = "DNA damage responses, ISS, International Space Station, NASA One-Year Mission, NASA Twins Study, space radiation environment, telomeres",

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AU - Luxton, Jared J.

AU - McKenna, Miles J.

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AU - George, Kerry A.

AU - Zwart, Sara R.

AU - Crucian, Brian E.

AU - Drel, Viktor R.

AU - Garrett-Bakelman, Francine E.

AU - Mackay, Matthew J.

AU - Butler, Daniel

AU - Foox, Jonathan

AU - Grigorev, Kirill

AU - Bezdan, Daniela

AU - Meydan, Cem

AU - Smith, Scott M.

AU - Sharma, Kumar

AU - Mason, Christopher E.

AU - Bailey, Susan M.

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N2 - Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.

AB - Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.

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KW - ISS

KW - International Space Station

KW - NASA One-Year Mission

KW - NASA Twins Study

KW - space radiation environment

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Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

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Keywords

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