Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sara R. Zwart, Brian E. Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew J. Mackay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. Bailey

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.

Original languageEnglish (US)
Article number108435
JournalCell Reports
Issue number10
StatePublished - Dec 8 2020
Externally publishedYes


  • DNA damage responses
  • ISS
  • International Space Station
  • NASA One-Year Mission
  • NASA Twins Study
  • space radiation environment
  • telomeres

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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