Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sara R. Zwart, Brian E. Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew J. Mackay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. Bailey

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Consistent with findings first observed for NASA's One-Year Mission twin astronaut, Luxton et al. report spaceflight-specific telomere elongation in ISS crewmembers on shorter duration missions. Signatures of persistent DNA damage responses in the space radiation environment are also observed, providing potential mechanistic insight into telomere maintenance pathways during spaceflight.

Original languageEnglish (US)
Article number108435
JournalCell Reports
Volume33
Issue number10
DOIs
StatePublished - Dec 8 2020
Externally publishedYes

Keywords

  • DNA damage responses
  • ISS
  • International Space Station
  • NASA One-Year Mission
  • NASA Twins Study
  • space radiation environment
  • telomeres

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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