Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging

Haiying Cheng, Yumei Yan, Timothy Q. Duong

Research output: Contribution to journalArticle

96 Scopus citations


Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is "non-random" and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.

Original languageEnglish (US)
Pages (from-to)10214-10219
Number of pages6
JournalOptics Express
Issue number14
StatePublished - Jul 7 2008


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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