Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging

Haiying Cheng, Yumei Yan, Timothy Q. Duong

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is "non-random" and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.

Original languageEnglish (US)
Pages (from-to)10214-10219
Number of pages6
JournalOptics Express
Volume16
Issue number14
DOIs
StatePublished - Jul 7 2008
Externally publishedYes

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blood flow
statistical analysis
lasers
contamination
retina
blood vessels
rats
artifacts
spatial resolution
sensitivity

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging. / Cheng, Haiying; Yan, Yumei; Duong, Timothy Q.

In: Optics Express, Vol. 16, No. 14, 07.07.2008, p. 10214-10219.

Research output: Contribution to journalArticle

Cheng, Haiying ; Yan, Yumei ; Duong, Timothy Q. / Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging. In: Optics Express. 2008 ; Vol. 16, No. 14. pp. 10214-10219.
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