Telomeres, the nucleolus and aging

F. Brad Johnson, Robert A. Marciniak, Leonard Guarente

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging: the nucleolus. The accumulation of ribosomal DNA circles is a cause of aging in this organism. The possible relevance of this mechanism to human aging is also being considered.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number3
StatePublished - Jun 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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