Telomere length in psychiatric disorders

Is it more than an ageing marker?

Nancy Monroy-Jaramillo, Elena Dyukova, Consuelo Walss-Bass

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Psychiatric and substance-use disorders have been associated with premature biological ageing. Telomere length (TL), considered an ageing marker, has been analysed in psychiatric disorders, and to a lesser extent in substance-use disorders, with recent findings suggesting TL may be related to disease pathology. Methods: We conducted a critical and non-systematic literature search of TL studies published up to June 2016 in psychiatric and substance-use disorders, focussing on studies describing mechanisms, including studies linking telomere biology with genetic factors, stress and mitochondrial alterations (104 studies selected). Results: Patients with major depressive disorder and anxiety appear to have shorter leukocyte telomeres compared to controls. Inconclusive results are found for other psychiatric disorders and for substance-use disorders. This may be due in part to differences in medication treatment and response, as studies suggest that some psychotropic medications may modulate TL. Importantly, some studies establish a relationship between telomere machinery, stress and mitochondria function in psychiatric and substance-use disorders. Conclusions: While further longitudinal studies considering telomere genetics are needed to clarify the cause–effect link between telomeres and mitochondria function in psychiatric and substance-use disorders, the recent findings linking these biological processes suggest that telomeres may be more than ageing markers.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalWorld Journal of Biological Psychiatry
DOIs
StateAccepted/In press - Jan 24 2017
Externally publishedYes

Fingerprint

Telomere
Psychiatry
Substance-Related Disorders
Mitochondria
Premature Aging
Biological Phenomena
Major Depressive Disorder
Longitudinal Studies
Leukocytes
Anxiety
Pathology

Keywords

  • ageing markers
  • psychiatric disorders
  • substance-use disorders
  • telomerase activity
  • Telomere length

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Telomere length in psychiatric disorders : Is it more than an ageing marker? / Monroy-Jaramillo, Nancy; Dyukova, Elena; Walss-Bass, Consuelo.

In: World Journal of Biological Psychiatry, 24.01.2017, p. 1-19.

Research output: Contribution to journalArticle

Monroy-Jaramillo, Nancy ; Dyukova, Elena ; Walss-Bass, Consuelo. / Telomere length in psychiatric disorders : Is it more than an ageing marker?. In: World Journal of Biological Psychiatry. 2017 ; pp. 1-19.
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